The Islet Regulome Browser

The Islet Regulome Browser is a visualization tool that provides access to interactive exploration of pancreatic islet genomic data.

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants. Pasquali L, et al. Nat Genet. 2014 Feb;46(2):136-43. doi: 10.1038/ng.2870.

Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Morán I, et al. Cell Metab. 2012 Oct 3;16(4):435-48. doi: 10.1016/j.cmet.2012.08.010.

Human Pancreatic Cell lncRNAs Control Cell-Specific Regulatory Networks. Akerman I, et al. Cell Metab. 2016 Dec 28. doi: 10.1016/j.cmet.2016.11.016.

A map of open chromatin in human pancreatic islets. Gaulton KJ, et al. Nat Genet. 2010 Mar;42(3):255-9. doi: 10.1038/ng.530.

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Parker SC, et al. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17921-6. doi: 10.1073/pnas.1317023110.

Integration of ATAC-seq and RNA-seq Identifies Human Alpha Cell and Beta Cell Signature Genes. Ackerman AM, et al. Mol Metab 2016 Mar;5(3):233-44. doi: 10.1016/j.molmet.2016.01.002

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Cebola I, et al. Nat Cell Biol. 2015 May;17(5):615-26. doi: 10.1038/ncb3160

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Morris AP, et al. Nat Genet. 2012 Sep;44(9):981-90. doi: 10.1038/ng.2383.

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Scott RA, Nat Genet. 2012 Sep;44(9):991-1005. doi: 10.1038/ng.2385.